Proper tissue restoration requires a coordinated multicellular response and adaptation. Identifying the cellular and molecular factors that regulate homeostatic repair is crucial for developing novel and effective strategies to promote tissue repair and regeneration. Stem cells and progenitor cells within epithelial barrier tissues locally drive homeostatic repair and regeneration. These cells engage in multicellular interactions with other tissue cells, such as immune cells, to support tissue health and regulate inflammatory responses. In the Lab, we continue to explore the cellular circuits between epithelial stem cells, immune cells, endothelial cells, fibroblasts, and other tissue constituents, aiming to systematically map the language of tissue repair and leverage this knowledge to enhance tissue regeneration.